Sentence examples for mutations may act from inspiring English sources

It is hidden by the fat lollipop head, whose rapid mutations may act as a decoy, attracting the immune system.

These data have lead to the hypothesis that FAD-linked PS mutations may act through a partial loss of function mechanism [7].

Our observation that in chick, motor neuron loss mediated by exogenous TDP-43 expression requires the integrity of the TDP-43 C-terminal section in addition to its N-terminally localized RNA-binding function could further point to the possibility that ALS/FTLD-linked C-terminal TDP-43 missense mutations may act through a pathway determined by inherent TDP-43 RNA-binding function.

Altogether, assuming that Huh7-derived cells and tamarin hepatocytes provide similar cellular factors involved in GBV-B genome replication, our data suggest that these adaptive mutations may act to facilitate a later step in the virus life cycle, possibly involving packaging and/or particle assembly.

Thus, motor neuron loss mediated by exogenous TDP-43 expression requires both, N-terminally localized inherent RNA-binding function, as well as the integrity of the C-terminal section suggesting the intriguing possibility that C-terminal TDP-43 missense mutations may act through a pathway determined by inherent TDP-43 RNA-binding function.

Mutations may act by disrupting protein processing in vivo, a hypothesis that is supported by evidence from transgenic mice (Shen et al., 2011).

These results suggest that a mechanism involving base mutation may act on first introns to elevate their GC content.

However, this mutation may act by allowing more flexibility to helix 10, so preventing the correct positioning along the helix of Phe or other residues that do interact directly with the inhibitor.

As αB-crystallin interacts with αA-crystallin, a mutant αB-crystallin with the P20S mutation may act in a dominant negative manner, thereby interfering with the function of αA-crystallin and leading to the formation of cataracts early in the lives of individuals who carry the mutation.

It can be caused by both external factors (tobacco, chemicals, radiation, and viruses) and internal factors (hormones, immune conditions, and mutations) that may act together or in sequence to instigate or promote carcinogenesis (American Cancer Society 2011).

Van-Gogh-like 2 is frequently methylated in MSI-CRCs with BRAF mutation and may act as a tumour suppressor gene, counteracting WNT/ β-catenin signaling.