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The mutations make the channel, called NaV1.7, more easily blocked than it usually is.
Involvement of more genes and mutations make the genetics of leucistic animals complex (Householder 2003), and 'the genetic pathways influencing coat coloration are still only poorly described' (Cieslak et al. 2011).
The German government had asked the council to study the issue in the wake of the fierce debate over two studies a few years ago one led by Ron Fouchier of Erasmus MC in Rotterdam, the Netherlands, and the other by Yoshihiro Kawaoka at the University of Wisconsin, Madison that sought to find out which genetic mutations make the H5N1 bird flu virus more easily transmissible between humans.
In addition, the mutations make the inflorescence transcriptome less similar to mature pollen and seed transcriptomes.
These small-effect mutations make the nature of the response more difficult to analyze.
The genetic heterogeneity and the spectrum of phenotypes associated with different mutations make the diagnosis of BOR sometimes difficult.
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Dysfunction of this protein due to mutations makes the route vulnerable to viral diseases.
Mutations making the flu more lethal and drug-resistant have been spotted in many countries, but thus far only in small numbers of isolated cases.
Together, the four mutations made the engineered virus transmissible through the air, although it didn't kill the ferrets who caught it, or even make them very sick.
Certain mutations made the potassium channels carry less current and open more slowly than normal channels.
Fouchier's group used the popular ferret model, and as reported in the conference newspaper, The Influenza Times, a mere five mutations made the virus transmissible.
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