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Together, the four mutations made the engineered virus transmissible through the air, although it didn't kill the ferrets who caught it, or even make them very sick.
Certain mutations made the potassium channels carry less current and open more slowly than normal channels.
Fouchier's group used the popular ferret model, and as reported in the conference newspaper, The Influenza Times, a mere five mutations made the virus transmissible.
The destabilizing CTL-escape mutations L259S, R384G, and V280A were inaccessible to NP during much of its evolutionary trajectory, but were fixed after stabilizing mutations made the protein permissive to their occurrence.
In both cases, the mutations made the PIC more likely to remain in the open conformation and continue scanning at incorrect or suboptimal start codons, making it more likely that translation begins at the correct AUG start codon.
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Dysfunction of this protein due to mutations makes the route vulnerable to viral diseases.
Mutations making the flu more lethal and drug-resistant have been spotted in many countries, but thus far only in small numbers of isolated cases.
The mutations make the channel, called NaV1.7, more easily blocked than it usually is.
Involvement of more genes and mutations make the genetics of leucistic animals complex (Householder 2003), and 'the genetic pathways influencing coat coloration are still only poorly described' (Cieslak et al. 2011).
Natural selection operates on mutations, making the path of natural selection unpredictable, regardless of how well we understand the underlying principles.
In addition, the mutations make the inflorescence transcriptome less similar to mature pollen and seed transcriptomes.
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