Sentence examples for mutations localized in from inspiring English sources

To date, the oncogenic role of ALK in NB cells is best defined by studying the biological effects of specific ALK mutations localized in its tyrosine kinase domain15,16,17,18.

We hypothesized that AR point mutations localized in the ligand binding domain and associated with normal 3H-DHT Bmax and Kd may be reversible, and proved this by using the new AR HCA technology and conventional assays, such as NC-TDI.

Three of the latter showed 2 mutations localized in different stretches.

Therefore, the only conspicuous difference between the two viruses is mutations localized in the 6K1/CI junction.

Moreover, we show that missense MLK3 mutations, localized in the different domains of the protein, harbour transforming and tumorigenic potential, in vitro and in vivo.

All mutations localized in or close to the linker domain, except for the A359T, caused relatively severe replication stalling over the whole length of mtDNA.

Colorectal tumours are typically accessible for molecular characterization and common mutations localize in specific exons.

In fact, differences were observed both in the level of inclusion of alternative normal exons and in the magnitude of changes caused by mutations localizing in these exons (figs. 4, 5).

In general consistency with the report by Hughes et al. (Hughes et al., 1988), we also found the molecular determinants of two fadR super-repressor strains TH182 and TH183, each of which is a single point mutation localized in C-terminal ligand binding domain (G638A, R213H in TH182 and G647A, G216E in TH183) (not shown).

This historical analysis showed that AR-R840C, AR-F764L and AR-P766S shared these following common features; they were point-mutations localized in the ligand binding domain with normal 3H-DHT Kd and Bmax.

The W474C mutation localized in the helicase domain of Twinkle showed a slightly different effect on replication.