Sentence examples for mutations limits from inspiring English sources

Although the role of G13D mutation in the resistance to anti-EGFR MAbs is not clear because of the contrasting results that have been reported up to now (Peeters et al, 2011; Tejpar et al, 2012), the fact that the COBAS KRAS kit does not tell between codons 12 and 13 mutations limits the possibility to increase our knowledge on the outcome of these different mutations.

When compared to the constant fitness case, cooperative lineage expansion with early mutator mutation limits the importance of mutator pathways when few oncogenic mutations are required for cancer (C = 2) and to some extent at C = 3 with a low wild type mutation rate (kmut), but for higher values of C, α50% continues to be well within commonly observed ranges.

As the effect of deletions and point mutations limited to the 5'UTR of Dp140 could not be confidently predicted, but protein truncating mutations in DMD coding exons are of known pathogenicity, subjects with mutations involving the Dp140 transcript were subclassified into two groups.

The models show that harmful mutations limit how quickly the antigens can evolve.

However, there is no appropriate RE for the vast majority of pathological mutations, limiting their usefulness.

The much lower frequency of RET/PTC rearrangement and RAS mutations limited their utility in FNA diagnosis.

Theoretically, all these deletion mutations limited to inx-21 could produce a hybrid N-terminal INX-22/C-terminal INX-21 molecule that might react with C-terminal-targeted anti-INX-21 antibodies and rescue inx-21 function.

For example, Strelkowa and Lässig [ 36] and Koelle et al. [ 40] raised alternative hypotheses concerning whether periodic positive sweeps in human influenza were due to a limiting supply of beneficial mutations, or by a high supply rate with competition between beneficial mutations limiting the fixation rate.

We determined that the mutation limits respiration, causes a moderate deficiency of ATP and increases the level of lactate.

The extremely low frequency of the mutation limits the determination of an association to overweight and obesity (p = 1; Table 2).

We showed that IGF signaling is hyperactive under oxidative stress, and thus, it seems that IGF-1R+/− mutation limits damage and ameliorates survival by blocking acute overreaction to IGF-I.