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Mutations likely to be disease-causative were found in six of the eight patients.
Turning to more subtle mutations, we used MAPP to calculate the fraction of nonsynonymous mutations likely to be deleterious43,44.
The study findings offer insight into new mutations likely to resist treatments based on the degree that specific mutations drive the growth and evolution of cancer, and the potential of therapeutic that may be able to stop deviant gene function.
Efficient sampling of mutations likely to affect enzyme function has been conducted both experimentally and, on a much greater scale, computationally, with remarkable improvements in substrate selectivity and specificity and in the de novo design of enzyme activities within scaffolds of known structure.
This epitope is of particular interest because the conserved Gag protein forms the essential capsid of HIV-1 (Zhao et al., 2013), with mutations likely to impose a fitness cost.
In addition, either alanine substitutions or mutations likely to disrupt (non-conserved replacement) or imitate (conserved alteration) interactions were substituted (Figure 5B).
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This is the first example of a BRCA1 mutation likely to be derived from a common founder in Scotland.
Loss-of-function mutations in nhaA suppress along with a mutation likely to lead to gain-of-function or altered function in trkB.
The BRCA1 exon 13 6-kb duplication, a mutation likely to be derived from a British ancestor (The BRCA1 Exon 13 Duplication Screening group, 2000), was found once.
These mutations likely contributed to the "raw material" fueling the genomic changes (see also the response to the first reviewer).
We reasoned that these common mutations were likely to represent mutations that arose during growth of the ancestral strain prior to transformation.
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