Sentence examples for mutations lie in from inspiring English sources

None of the mutations lie in the H10 helix or the conserved extreme C-terminus that were recently shown to interact with MinC in E. coli [30], [31].

The D56N and H125N mutations lie in the conserved phosphodiesterase motif of Mre11, and the mutant proteins have no in vitro endonuclease activity [18], [37]; however, they are able to form a complex with Rad50 and Xrs2.

The causative mutations lie in the COL7A1 gene.

These C-terminal mutations lie in the BRICHOS domain of SFTPC.

The sis7 mutations lie in the same gene as the previously identified nced3/sto1 [ 27] mutants.

The majority of the pathogenic mutations lie in the genes encoding mitochondrial tRNAs.

An invariant pattern of splicing was observed for the constitutive exons but intriguingly for the mutations lying in alternative exons, both the mutated and the normal alleles showed variability in the ratio of exon inclusion.

Hence, it is possible that the application of AOs to treat a wide variety of human gene mutations lies in therapeutic alternative splicing.

Two mutations lay in each of the ndh and qoxB genes, and single insertions were found in ctaB and mhqR.

The G2019S mutation affects the kinase domain of the protein, with other common mutations lying in the GTPase domain or in the protein interaction domains.

As in the model proposed by Wanrooij et al., we found that each of the fibroblast cultures from patients A D (that had the most severe cellular depletion) had at least two POLG1 mutations lying in catalytic domains.