Sentence examples for mutations leads to from inspiring English sources

However, CRC cell-line data has demonstrated that treatment with vemurafenib for BRAF V600E mutations leads to a powerful feedback activation of EGFR, leading to continued proliferation.

Naumann, M. et al. Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.

Combining tam and osd1 mutations leads to a failure in the prophase to meiosis I transition during male meiosis and to the production of tetraploid spores and gametes.

Conclusions: Protease I54M frequently appears after amprenavir therapy, and when combined with pre-existing mutations, leads to high-level amprenavir resistance and treatment failure.

Howe S, Mansour M, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H et al. Insertional mutagenesis in combination with acquired somatic mutations leads to leukemogenesis following gene therapy of SCID-X1.

Thus, RNAi mediated silencing of Nf-kB subunits in DLBCL cells with these mutations leads to dramatic reduction in proliferation, compared to DLBCL cells that harbor other non Nf-kB related mutations.

The mutations lead to reduced methyltransferase activity, leading to global hypomethylation and site-specific hypermethylation.

Cancer-relevant KRAS mutations lead to loss of K-Ras GTPase activity, leading to constitutive signaling.

Occasionally, genetic mutations lead to prion diseases that run in families.

SCN5A mutations lead to a wide spectrum of cardiovascular disorders.

Do particular diets or genetic mutations lead to autism?