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Exact(2)
In addition to the insertion and 5 synonymous mutations, it contains 2 non-synonymous but conservative mutations.
Each of the double substitutions also retains the ligand binding features of the single mutations it contains.
Similar(57)
A similarity matrix which is called mutation matrix and it contains a set of 210 numerical values, 20 diagonal and 20 × 19/2 off-diagonal elements used for sequence alignments and similarity searches.
We sequenced the erg26 -1 allele, previously unreported for the nature of the mutation, and found that it contains a G244D mutation resulting from a cytosine to thymidine change.
In addition, it contains mutations that eliminated almost all of the naturally occurring free carboxyl groups on g8p that may be susceptible to EDC conjugation.
Gβ is most severely affected in binding to Gα when it contains mutations in the region that interacts with the N terminus of Gα, indicating that the N terminus is crucial in mediating the interaction with Gβ [ 56].
One which is similar to ADAR1, one similar to ADAR2, and a third one that we would predict to be inactive because it contains mutations at key residues which are involved in catalysis.
However, it contains sequence mutations that likely lead to a truncated protein making it unlikely that this protein is functional.
The COSMIC dataset (CSM) differs from the others in that it contains somatic mutations observed in various cancer types.
A gene can be found to be a SMG because it contains driver mutations that are selected during tumorigenesis, and therefore can contribute to disease progression.
Moreover, although overexpressed in the venom apparatus (Table 3 and Additional file 7: Figure S3), it contains two mutations previously described to strongly reduce the enzymatic activity of human γ-GT1 [ 28, 29].
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