Sentence examples for mutations is weak from inspiring English sources

Selection against these mutations is weak because under natural conditions, most individuals die for other, external reasons before aging manifests itself.

Thus, P. esculentus represent 'hemiclones' [ 27] in which selection against deleterious mutations is weak because the clonal genome transmitted by the parasite is constantly sheltered by the sexual genome of the host [ 26].

There is only a slight enrichment of singleton non-synonymous variation over synonymous variation, suggesting that purifying selection on the mitochondrial lineages recently hit by non-synonymous mutations is weak.

This hypothesis is consistent with the theoretical prediction that selection to compensate for mutations is weak, whereas selection to maintain the optimal gene expression is strong (Hurst and Randerson 2000) and with the observation that mammalian genes possess abundant variation for such optimization (Rockman and Wray 2002).

The reason is that selection against harmful mutations is weaker in population with small sizes and disadvantageous mutations can drift to fixation.

We expect, however, that D1and D3should not be strongly affected as long as selection against synonymous mutations is weaker than against non-synonymous mutations.

Assuming that most mutations affecting phenotype are—at least individually neutral or deleterious (Kimura 1983), if selection against such mutations is weaker in GroEL clients than nonclients due to a buffering effect (Tokuriki and Tawfik 2009a), then clients ought to evolve faster than nonclients.

The Su z 21.a1, and Su z 2De26 mutations were weak suppressors of TPE and the Su z 21.b7 mutation was a moderate suppressors of TPE.

Although meta-analyses has indicated that K-Ras gene mutations are weak prognostic markers of poorer outcome in NSCLC, results from individual studies have been inconsistent (Huncharek et al, 1999; Mascaux et al, 2005; Tsao et al, 2007).

Furthermore, v-Myb proteins which contain both sets of these mutations are weaker transcriptional activators relative to proteins which lack these mutations.

Thus, one could intuit that better adapted species have fitness distributions where beneficial mutations are weaker on average, but it may be harder to explain why the rate of adaptive mutations should be higher in that case.