Sentence examples for mutations is warranted from inspiring English sources
Thus careful evaluation of historical functional analysis of classical mutations is warranted.
We biologically validate the potential impact of deletions in SLC22A16 at 6q21 and future biological analysis of additional CNAs and mutations is warranted.
In this regard, greater understanding of the changing biology of E2F1 especially in the context of cancer-specific mutations is warranted to ensure that E2F1 activity can be leveraged for the benefit of melanoma patients.
We sought to ascertain the prevalence of PALB2 mutations in these women due to the high estimated breast cancer risk associated with at least some PALB2 mutations and to further consider if clinical testing for these mutations is warranted.
Because most metaplastic breast carcinomas overexpress EGFR without gene amplification, further studies to evaluate EGFR activating mutations are warranted.
Although several phase III studies in genotypically defined groups of patients are already available, further prospective studies assessing the role of uncommon EGFR mutations are warranted.
The isolates were not available for sequencing, but, further studies that look at the presence of these low level mutations are warranted.
Furthermore, PIK3CA mutations were always found in esophageal cancer [ 23, 24] and further functional analyses of the mutations are warranted to determine whether or not they may be potentially useful targets of therapy for esophageal cancer [ 25].
Therefore, treatments guided by presence of the mutation are warranted.
Sensitivity analysis identifies the degree of breast cancer risk reduction due to prophylactic oophorectomy as a key determinant of life expectancy gain.Further study of the impact of prophylactic oophorectomy on breast cancer risk in BRCA1/2 mutation carriers is warranted.
Both studies [ 10, 11], including our own, are based on small-sized BRCA1 positive populations, therefore, validation in a larger cohort of BRCA1 mutation carriers is warranted.
