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Data regarding prevalence of multi-drug resistant tuberculosis (MDR-TB) and associated common mutations is scarce from Punjab region.
Data about antiretroviral (ARV) drug efficacy and resistance mutations is scarce.
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Germline MLH1 and MSH2 mutations are scarce in young colorectal cancer patients with negative family history of the disease.
When beneficial mutations are scarce, they can be fixed before a secondary mutation arises, and adaptation takes place through the sequential fixation of mutations [ 3].
Information on clinical benefits of ivacaftor in this particularly rare mutation is scarce at present [ 6].
Studies involving promoter mutation are scarce because the studies that define the relationship between the mutation and the disease are laborious and the effect of this class of mutation can be subtle [43].
Similarly, in vivo models are difficult to propagate and as a result, preclinical glioma models carrying the IDH1 or IDH2 mutation are scarce.
Yet, experimental data on the molecular consequences of the various novel missense mutations identified in NBS is scarce and mainly refers to the mild temperature-sensitive Y42H mutation (18, 21, 22).
By contrast, data available of predictive value of resistance mutations in pediatric population is scarce.
So far, none of these has been identified as a reproducible prognostic biomarker, except V600E BRAF mutation, which seems to be an independent biomarker of poor prognosis in MSS stage III CCs 37. Regarding PI3KCA mutations, reports are scarce and results are equivocal 16– 20.
There is scarce information about HIV mutations in persons failing HIV treatment in North of Brazil.
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