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Thus, the presence of activating GNAS mutations is relatively organ-specific.
In Icelandic BC women, it seems that the rate of BRCA1 mutations is relatively low.
However, the frequency of these mutations is relatively low, and whether SMAD4 plays a key role in colorectal tumorigenesis is still unclear.
In contrast, the mutations at synonymous sites are largely neutral and thus the accumulation of such mutations is relatively constant over time.
Thus, a positive or negative association of malignancy with HFE genotype in a population in which the frequency of HFE mutations is relatively high may be due to chance association with other genetic or environmental factors.
The first finding to be mentioned is that, even in a group of breast cancer with a family history, the incidence of BRCA mutations is relatively low (about 25%) in our population of Italian women.
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If particular adaptive pathways are accessible only by specific types of mutations, mutators may be able to access them more readily because those types of mutations are relatively more common.
Although the majority of these mutations are relatively infrequent at diagnosis (at least at the population-level) they tend to accumulate as the disease progresses or at relapse.
Although these mutations are relatively rare, their discovery, reported in the January issue of Nature Genetics, could help point the way to other genes behind inherited epilepsies, which are thought to account for about 40% of all forms of the disease.
Somatic mutations are relatively common in plants, but usually only affect a portion of the meristem.
Because somatic mutations are relatively rare events, our analysis focuses on microsatellites (MS; repetitive DNA sequences with relatively high mutation rates) in mismatch repair (MMR -deficient organisMMR -deficient
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