Sentence examples for mutations is realized from inspiring English sources
Indeed, approximately 20% of melanoma patients treated with the BRAF inhibitors vemurafenib or dabrafenib develop keratoacanthomas and/or squamous cell carcinomas of the skin that can harbor activating RAS mutations (mostly HRAS), suggesting that the oncogenic potential of these RAS mutations is realized specifically in the context of drug treatment [ 6].
Not all mutations are realized with equal probability; those that are more beneficial are more likely to occur.
While a single mutation (K7R or K10R) partially reduces the ubiquitination profile of MAVS (data not shown), MAVS ubiquitination was strongly inhibited when a double mutation was realized (K7R/K10R).
In the protein universe, selection is realized through function: mutations leading to loss of function are rarely observed.
This potential bias is realized to its fullest extent when the DFE of beneficial mutation is tested in the environment from which the mutants were originally collected.
This concern is realized in the case of SFS-based statistics, for which statistical power to detect selection never exceeds 50% when mutation rate is high (fig. 2).
This expansion is realized in different ways.
This suggests that once the third most common pathways involving single mutations have been realized, the same evolutionary principles can be applied to double mutations starting with double mutations in negative regulators, followed by double mutations in one negative regulator and one promoter mutation.
Current estimates suggest a 17-hr generation time under selection and clones have to reach a much more substantial colony size before the rarer secondary purR or purO mutation could be realized.
Moreover it should be realized that P53 mutation occurs at last stage of CC tumorigenesis and is not observed in all neoplastic cells.
These evolutionary forces are realized through introducing new mutations during meiotic recombination and fixation with the help of DNA methylation and transcriptional mechanisms.
