Sentence examples for mutations is potentially from inspiring English sources

Despite relatively low rates of virological failure in cohorts of long-term treated patients, the risk of emerging or accumulating HIV drug resistance mutations is potentially high in undiagnosed virological failure.

Because epigenetic defects, unlike genetic mutations, are potentially reversible, this area of investigation has tremendous potential for translational and therapeutic application.

Importantly, many of the identified mutations are potentially therapeutically targetable, with agents currently available or in various stages of clinical development.

By comparing the various analyses it could be safely concluded that except P437L and A379V mutations, all other mutations were potentially deleterious affecting various structural aspects of RING2 domain architecture.

The hot spot mutations are potentially useful as surrogate biomarkers for acquired drug resistance in ongoing clinical trials and future treatments and for the design of the next generation of mTOR-targeted drugs.

In silico analyses indicate a substantial proportion of these mutations are potentially deleterious.

Importantly, a large number of these oncogenic mutations are potentially actionable with novel therapies.

Taken together, our data suggest that the tested mutations were potentially disruptive and destabilizing for the protein.

Mutations can be more readily assimilated in a diploid than in a haploid organism, since deleterious mutations are potentially buffered by a functional version (Thompson et al., 2006).

However, several pieces of evidence indicate that a subset of recurring mtDNA mutations are potentially functional and may even offer adaptive value.

Few of the identified mutations were potentially ?druggable?, illustrating the challenges of developing new treatments for this aggressive breast cancer subtype.