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It therefore seems that the primary effect of TTD mutations is on TFIIH stability and that this effect is conserved between human and flies.
Whilst the CFTR protein is expressed in many internal organs, the major effect of such mutations is on the respiratory, gastrointestinal, and reproductive tracts, causing, in each of these sites, obstruction by thick, viscous secretions.
In this gene set the impact of somatic mutations is on average more deleterious than the impact of random mutations from the null (see Table 2 and Figure 3).
The effect of dCTCF mutations is on the maintenance rather than on the establishment of the imprint, and is specific to the Dp(1 f LJ9 mini-X chromosome.
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While the study of mtDNA mutations is on-going and of great importance, the study of physical damage to mtDNA that may cause mutations or genome instability is a field that is still relatively undefined.
In this case a functional protein is produced only if the mutations are on different genes.
In the cis test, a functional protein is always produced regardless of whether both mutations are on the same gene or on different genes.
Common resistance mutations are on commercial line-probe assays, and explain ∼85 95% of observed resistance to the two primary first-line drugs (isoniazid and rifampicin 27,28,29.
Unless otherwise noted, the mutations are on the IgG1 subclass.
Seventeen mutations were on five lists; seven mutations were on four lists; and seven mutations were on three lists.
Thirty-one mutations were on five lists; 12 mutations were on four lists; and eight mutations were on three lists.
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CEO of Professional Science Editing for Scientists @ prosciediting.com