Exact(22)
The present assay named FACIM II (Functional Analysis of Chemical-Induced TP53 Mutations) is more convenient than the FACIM I and more inducible than the SOS Chromotest to detect direct-acting mutagens in the environment.
It is apparent from our B-SIFT analysis that the systematic prediction of activating mutations is more complex than the analogous prediction of deleterious mutations.
The absence of a C4BP effect in cells from patients with CD40 mutations is more difficult to reconcile with our data, although it is possible that the mutation caused a more generalised defect rendering cells unresponsive to TNFr mediated stimuli.
Hereditary breast cancer (e.g. BRCA1 and 2 mutations) is more frequent in young women with breast cancer but this has not implied a worse survival in most studies [40].
The prognostic value of IDH1/IDH2 mutations is more controversial.
This suggests that the observed change in ALK-crizotinib due to mutations is more reliable.
Similar(38)
Mutator mutations are more likely to occur early, and to occur when more oncogenic mutations are required to create a tumor.
The present study revealed that PIK3CA mutations were more common in MSI and BRAF mutated tumours.
SDHB and SDHD mutations are more common, whereas SDHA and SDHC mutations are rare.
Somatic mutations are more common, and might account for malignant transformation of sporadic tumors.
In addition, smaller tumors (<4 cm) with PBRM1 mutations are more likely to exhibit stage II pathologic features.
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