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Because the effective population of each line is one, the ability of natural selection to fix or eliminate mutations is minimized.
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Both of these positive and negative effects induced by acceptor stem mutations were minimized by compensatory mutations.
By creating a single X-chromosome bottleneck each generation, selection on new germ-line mutations was minimized, except against those mutations causing death or sterility in males.
In particular, the assignments of amino acids to codons are such that the detrimental effect of mistranslation and/or mutation is minimized.
Therefore, selection bias is minimized.
This way build up is minimized.
Theoretically, the background of non-productive or deleterious mutations can be minimized by attenuating mutagen dosage, screening for parental strains that contain productive mutations, followed by trait-enhanced mutant strain recombination to combine mainly productive mutations into a single strain.
Insertional mutations can be minimized when plants carry only a single T-DNA insertion.
Under this scenario the overall impact on individual fitness of deleterious mutations would be minimized but the shaping by NBDM of the primary structure of many genes would be epiphenomenal and these genes' deleterious mutability under NBDM could appear much less optimized, if at all, were it to be assessed in isolation (see below).
"He is minimizing his dependence on Medvedev".
By contrast, the risk of genetic mutations or cell aging could be minimized, if MSCs are cultured for less than 16 weeks.
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