Sentence examples for mutations is mediated from inspiring English sources

Presumably, the protective effect associated with these mutations is mediated via different mechanisms that converge at the level of Nrf2 activation.

In agreement with the pharmacological studies, these data demonstrate that the main protective effect of ppk29 mutations is mediated via 3′UTR-dependent regulation of SEI, independent of PPK29 channel functions.

The Protective Effect of ppk29 Mutations is Mediated by SEI Channel Activity.

Similarly, it is unlikely that the effects of these other mutations are mediated by their size or hydrophilicity since mutation of Y520 to alanine failed to restore basolateral targeting of prestin (Fig. 5).

These mutations are mediated by an error-prone DNA polymerase, DNA polymerase IV, which is regulated by RpoS, the stress response sigma factor [ 29], the heat-shock chaperone GroES [ 29], and polyphosphate kinase [ 30].

HbF increases secondary to KLF1 mutations are mediated through the effects of KLF1 on globin gene expression and also through its effects on erythropoiesis, the membrane or on cell metabolism [ 92– 92].

The longevity effect of the daf2 gene mutation is mediated through daf16, the C. elegans homologue of transcriptional factor FOXO.

Furthermore, resistance to poly(ADP) ribose polymerase inhibitors and platinum-based chemotherapy in cancer patients harboring a BRCA1 or BRCA2 germline mutation is mediated in a proportion of cases by the acquisition of revertant mutations or intra-genic deletions that restore the open reading frame of BRCA1 or BRCA2[ 42] 42].

The 2.2 Å structure of Thr114Phe α1-antitrypsin demonstrates that the effects of the mutation are mediated entirely by well-defined partial cavity blockade and allows in silico screening of fragments capable of mimicking the effects of the mutation.

67 This oncogene cooperativity seen with concurrent mutations in KRAS and PIK3CA is mediated by Ras/p110α interaction and signaling through PDK1 that directly mediates p90RSK activity.

Resistance to INH is mediated by mutations in different genes in MTB, with katG [ 5] and inhA [ 6] being the most common.