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Accordingly, a wide range of genetic mutations is involved, and the same mutations may exhibit a different impact.
A telomere maintenance mechanism (either TERTp mutation or ATRX/DAXX mutations) is involved in >80% of gliomas and appears therefore as a unique feature in these tumors, offering the prospect of new therapeutic approaches.
This suggests that such mutations is involved in the early stage of oncogenesis of NSCLC, so that EGFR mutations should be investigated further in regard to oncogenesis of NSCLC, as well as considered for design of clinical trial of or selecting candidates of EGFR-targeting drugs.
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This establishes this gene as recurrently mutated in JAK2 V617F and MPL W515K/L negative ET, and suggests that TOP1MT mutations are involved, at low frequency, in the pathogenesis of ET. However, its functional consequences remain to be investigated.
Gene mutations are involved, but they aren't passed down from generation to generation.
We provide strong evidence that at least some of these mutations are involved in binding of sialic acid, a known receptor for the JC virus.
For example, in cavefish, we do not know what is the precise mutation that causes a change in gene expression level, or if multiple mutations are involved.
The clear lack of a relationship between the nucleotide distance in LTRs and flanking NRR sequences suggests that whatever the mechanism(s) acting on LTRs is, it does not extend its effects to the immediate flanking sequences (as far as mutations are involved).
Further genomic, genetic and functional analyses will be required to establish whether other mutations are involved in ATN + MF resistance in AS-ATNMF1.
For instance, in the case of cancer, it is generally acknowledged that genetic mutations are involved in the onset of the disease, but its manifestation is at the pathway functional signaling level [1], [2].
All three mutations are involved in DNA repair and replication.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com