Sentence examples for mutations is indicative from inspiring English sources

Positive selection, as determined by comparing the rate of non-synononous over synonomous mutations, is indicative of population level selection pressure at any particular residue, and also regions of the HIV genome that more readily accommodate sequence variation.

Although ELF3 is thus infrequently mutated (6.9%% borderline tumors and 6.5 % carcinomas), the shared characteristics of the four heterozygous mutations is indicative of a pathogenic role.

This mutually exclusive relationship between these two gene mutations has also been noted by Kandoth et al. "Mutual exclusivity" of mutations is indicative of a classic genetic interaction between genes that function in the same pathway.

The presence of polymorphic elements sharing specific mutations is indicative of the activity of a secondary source element, as polymorphic elements have recently retrotransposed and are therefore unlikely to have accumulated such mutations in parallel.

This pattern of mutations is indicative of strong negative selection and may occur because the clone has evolved to the point where it can no longer improve its affinity through mutation; any further replacement mutation thereby might lower the antibody affinity for its antigen.

In the case of a diverse family with shared fold, correlated mutations are indicative of allowed fluctuations also among structurally important residues.

The impact of tumour BRAF mutations was also assessed in retrospective and prospective retrospective analyses from some of these panitumumab studies, with data generally suggesting that these mutations are indicative of poor prognosis, irrespective of treatment received [ 12, 35].

While significant differences in the frequencies of complementary mutations are indicative of general strand-specific mutation biases, we noted, as have others, that particular mutations were likely over-represented amongst the spectra of mutations that we observed in our various evolution experiments.

Western blot analysis revealed pronounced decrease in the content of subunit 4 (cof4) of cIV in P4 P6 (Fig. 5C) and when the p50 was related to the cIV content, most extreme values of both parameters (Fig. 5D) found in lymphocytes harboring SURF1 and SCO2 mutations were indicative for confident diagnosis of cIV defect.

The recombination to mutation ratio is indicative of the contribution of recombination relative to mutation in generating allelic diversity [ 39] which can be measured by Nei's diversity index [ 42].

20 The prevalence of the mutation dhps540E is indicative of high SP resistance 21 and in other work, a spatiotemporal model was developed for the spread of the dhps540E marker in Africa.