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In particular, the distribution of mutations is highly associated with intrinsic molecular processes including transcription, chromatin organization, DNA replication timing, and DNA repair.
Nevertheless, the presence of such mutations is highly predictive of the development of these cancers.
Detecting these mutations is highly valuable in diagnosing MLN subtypes.
The prevalence of such mutations is highly variable between cancer (sub types [ 2, 22 ].
Conversely, the presence of EGFR-activating mutations is highly predictive of response to treatment with gefitinib or erlotinib [ 13, 14].
Since the phenotype associated with MUTYH mutations is highly variable, the diagnosis of MAP is difficult on clinical grounds alone [ 5- 7, 38, 39].
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Mutational frequency and type of somatic point mutations were highly variable among the different MPNSTs modeled, but very consistent when comparing primary tumors with matched orthoxenografts generated.
Figure 3: Pathogenic mutations were highly enriched in Tibetan highlanders.
Rapid reliable diagnostics of DNA mutations are highly desirable in research and clinical assays.
She and other women with BRCA1 or 2 mutations are highly likely to develop breast cancer at some point in their lives.
We found that the ratio of deleterious to tolerated mutations was highly negatively correlated with the effective population size (Fig. 6c and Supplementary Fig. 10).
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