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The prevalence of p53 mutations is highest in ovarian cancer (48.3%), followed by colorectal cancer (43.6%), oesophageal cancer (42.6%), head and neck cancer (41.5%), and lung cancer (38.4%) [ 10].
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The participants had not yet developed DCM by the time of this study but it is known that the penetrance of LMNA mutations is high [17].
TDR mutation rate remains low, but the rate of TDR-associated mutations is high.
Relative to a 2011 BALB/c genome, the number of mutations is higher than average, with many non-synonymous mutations.
Although the frequency of KRAS mutations is higher in sigmoid and rectum, the difference is not statistically significant.
However, the detection rate of mutations is higher if the new technique of next-generation sequencing (NGS) is applied.
In other words, we assume that a fraction of beneficial mutations is higher among mutations that increase the genome size than among mutations that decrease or preserve it.
I am not sure that the fraction of such mutations is high although I am not aware of such estimate in active site residues.
As reported, the probability of finding a novel pathogenic CDH1 missense mutation (including also non-missense mutations) is higher in GC low-risk areas.
For each gene, we test if the number of samples with 'driver-like' non-silent mutations is higher than that expected by the background mutation model M0.
This percentage of mutations is higher than prior reports for betel quid chewers, who have a mutation rate of 10% (31).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com