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The increase in human population size is likely to have been particularly relevant in this regard, given that the total occurrence of new mutations is higher when there are more individuals and because selection is more effective in larger populations (Hawks et al. 2007).
The selective advantage of escape mutations is higher during early infection and wanes later as a result of the decline in both CD8 T cell numbers and function and changes in CD4 T cell target cells [12].
Although the frequency of KRAS mutations is higher in sigmoid and rectum, the difference is not statistically significant.
However, the detection rate of mutations is higher if the new technique of next-generation sequencing (NGS) is applied.
Relative to a 2011 BALB/c genome, the number of mutations is higher than average, with many non-synonymous mutations.
tmVar performance for DNA mutations is higher than any other system when partial matching is used and below SETH when exact matching is considered.
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The participants had not yet developed DCM by the time of this study but it is known that the penetrance of LMNA mutations is high [17].
TDR mutation rate remains low, but the rate of TDR-associated mutations is high.
I am not sure that the fraction of such mutations is high although I am not aware of such estimate in active site residues.
Preliminary data from these families suggest that the penetrance of CDH1 gene mutations is high, ranging between 70 and 80% (Pharoah et al. 2001).
This may be true that plasmid DNA can transcribe RNA longer in the cells, thus off-target mutations are higher than that by RNA injection in the embryos.
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