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The research on gene mutations is fundamental and family screening by clinical examination, chest X-ray, research of pulmonary shunting, and abdominal color Doppler sonography is absolutely necessary.
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Protein side-chain mutation is fundamental both to natural evolutionary processes and to the engineering of protein therapeutics, which constitute an increasing fraction of important medications.
The location of the BRCA1 mutation is fundamental.
Published: October 17, 2013 The process of somatic mutation is fundamental to cancer development.
The mutation was fundamental: as a musician, Brabenec's saxophone and clarinet added new chromatics and textures - avant-garde jazz of the kind played by Soft Machine, Slavonic dances and klezmer rhythms changed the band's musical timbre, which had hitherto combined Velvet-esque rock with a distinctly Celtic edge to Jiri Kabes's violin.
The detection of V600E BRAF mutation in melanoma is fundamental since here BRAF inhibitors represent an effective treatment.
The loss-of-function of RUNX2, associated with polyA-expansion or with other mutations, is a fundamental pathogenetic mechanism of cleidocranial dysplasia (39).
Identifying causes of rate heterogeneity as well as specific variables that affect underlying mutation and substitution rates is fundamental to understanding the mechanisms that cause evolution of DNA sequences (reviewed in [ 7]).
With the understanding that SARS-CoV might be with humans for years to come, knowledge of the evolutionary mechanism of the SARS-CoV, including its mutation rate and emergence time, is fundamental to battle this deadly pathogen.
A better understanding of the frequencies of BRCA1 and BRCA2 mutations in such moderate risk patients is fundamental to our appreciation of the importance of these genes as a cause of disease in the general population.
A well-controlled lethal rate is fundamental for effective mutation and screening of the mutants.
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