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This work also demonstrates that while the introduction of mutations is frequent, the rate of substitution over longer time periods is many fold lower, in part due to purifying selection acting on nonsynonymous mutations.
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BRAF mutations are frequent in melanoma but their prognostic significance remains unclear.
(2015) demonstrate that passenger mutations are frequent in most genetically engineered congenic mice and persist even after extensive backcrossing.
We tested the hypothesis that these mutations were frequent in cancer genes, by studying again TP53.
In T-ALL, NOTCH mutations are frequent, occurring in about 55 60% of pediatric and adult T-ALL samples [2], [18].
Mitochondrial DNA mutations are frequent in various tumor types [3], and detected in preneoplastic lesions thereby indicating their occurrence at early stages of multistage tumor progression [5].
As expected, homozygous mutations were frequent in six tumor suppressor genes (81%), with the exception of APC, while the five oncogenes also had a relatively high frequency of homozygous mutations (20%).
TET2 mutations were frequent in RAEB1 (7/16, 43.8%).
NPHS1 mutations are frequent in Finland.
RUNX1 mutations were frequent in our series of CMML.
p53 mutations are frequent in MNU-induced rat colon tumors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com