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A buffering effect of deleterious mutations is expected if epistasis would be positive.
Therefore, if the FA pathway stimulates Rev1 during SHM, a reduction in these mutations is expected in FancG-deficient B cells.
Since our MS are highly unstable, mutations may have occurred in culture, hence the actual percent of WGA artifact mutations is expected to be lower.
As sequencing technologies improve, the proportion of validated mutations is expected to increase.
Accumulation of deleterious mutations is expected to increase variance among MA lines.
Accumulation of deleterious mutations is expected to reduce MA line fitness.
Similar(39)
Similarly, the burden of all functional categories is ordered by common expectations as to how often such mutations are expected to be functional.
Partly, this reflects the fact that the mitochondrial gene products are essential for life; that is, most mtDNA mutations are expected to be lethal.
The H547P, H547A, H547D, and H547R single mutations were tested because proline and alanine mutations are expected to be the most significant change in backbone conformation, while aspartic acid or arginine mutation is expected to introduce significant side-chain conformational disturbances due to their non-neutral electrostatic potentials.
The Y470H mutation is expected to destabilize the YYY motif by impairing both the Y470-Y548 and Y470-Y551 interactions, whereas the Y548H and Y551H mutations are expected to partially reproduce the effect of Y470H, as they only impair one of the Y470-Y548 and Y470-Y551 interactions.
FHM2 mutations predict reduced glial uptake of K+ and glutamate from the synaptic cleft whereas FHM3 mutations are expected to be associated with hyperexcitability of excitatory neurons.
More suggestions(15)
transfer is expected
deployment is expected
move is expected
mutations is performed
mutations is taken
mutations is known
mutations is shown
mutations is proposed
mutations is recommended
mutations is given
mutations is maintained
mutations is characterized
mutations is likely
mutations is correlated
mutations is based
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