Sentence examples for mutations is critical from inspiring English sources

On the genotypic level, the identification of somatic mutations is critical to detect the specific genomic abnormalities of cancer patients.

Understanding the biological consequences of COL4A1 and COL4A2 mutations is critical to the development of personalized therapeutic strategies.

The ability to detect the full spectrum of mutations is critical to the success of targeted sequencing projects.

Ultimately, an improved understanding of the clinical impact of PIK3CA mutations is critical for the development of optimally personalized therapeutics against breast cancer and other solid tumors.

Identifying cancer-associated mutations (driver mutations) is critical for understanding the cellular function of cancer genome that leads to activation of oncogenes or inactivation of tumor suppressor genes.

This has important consequences for any application of these measures to questions in evolutionary biology where the magnitude of fitness effects of mutations is critical [ 11– 131 31].

"I hope in the future we will be able to do that, work out which mutations are critical," Dr. Taubenberger said.

Thus, it is believed that activating K-ras mutations are critical for initiation of pancreatic ductal carcinogenesis.

Loss of FHIT expression and p53 mutations are critical events in the early stages of lung carcinogenesis.

Both types of mutations were critical, as reversion of either CDR or FWR mutations to the wild-type amino acids resulted respectively in a loss of affinity of CK138 and CK157 toward ELR+ CXC chemokines (Fig. 3d).

Nonetheless, the rate of de novo deleterious mutations and the strength of selection against de novo mutations are critical to understanding the genetic architecture of a disease.