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Considering that the total number of mutations is continuously growing, the reader is encouraged to use online databases (such as OMIM) in order to remain up to date.
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When the E. coli strain carrying a mutator was cultivated under gradually increasing temperature, genome-wide mutations were continuously generated during genome replication and the mutated strains with improved thermotolerance were autonomously selected.
However, new HCM-related mutations are continuously being revealed, and much more are still to be discovered.
At the molecular level, this cycle of environmental changes means that new mutations are continuously tested and fixed by selection if adaptive, which translates into higher rates of molecular evolution in genes controlling immunity in the hosts.
Our model predicts response patterns highlighting the interference of epitope and linked non-epitope loci with each other's evolution and function: Clonal interference limits functionality and speed of adaptation, because beneficial mutations are continuously lost in the competition between strains (Gerrish and Lenski 1998).
The total number of mutations identified is continuously growing due to mutational analyses in different patient cohorts by competitive research groups once a gene has initially been found.
Since the detection of the JAK2617F, the panel of known activating mutations in the CMPD is continuously increasing: PV patients who were JAK2V617F-negative were detected to carry somatic gain-of-function mutations within exon 12 of the JAK2 gene in 40% of cases in a recent study.
As clinical decisions will increasingly rely on molecular medicine, the power of identifying germline mutations must be continuously evaluated and improved.
The population is continuously evolved in every generation by the operators: reproduction, crossover and mutation.
(Radon is continuously replenished).
Follow-up is continuously updated.
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