Sentence examples for mutations is considerably from inspiring English sources

Thus, the probability of transformants having no untargeted mutations is considerably increased both by using high-fidelity Taq polymerases and by minimizing the size of the PCR fragment.

It is interesting to note that the number of dominant mutations was considerably smaller in the primary tumour than the metastatic lesion.

PolZeta appears to be involved in the repair of at least some of these DSBs, as the frequency of HO-induced base substitution mutations was considerably lower in an isogenic rev3 Δ strain (Holbeck and Strathern 1997).

We show that the number of abasic sites is significantly increased when the 3-methyladenine DNA glycosylase (Mag): AP endonuclease (Apn1) ratio is increased and that spontaneous frame shift mutation is considerably elevated when either Mag, or Mag plus Apn1, expression is elevated.

The frequencies of the c. 1080C>T and c.*543T>C variants were substantially higher in the Czech population whereas the frequency of the c. [833C; 844_845ins68] double mutation was considerably lower than in Africans.

The fraction of immunogenic mutations, in contrast, is considerably higher.

The ASSA server is capable of analyzing these categories of mutations; however it is considerably slower than the Shannon pipeline (30 s per variant).

Children and young adults with diabetes and a strong family history of diabetes: testing for HNF4A mutations Diabetes caused by mutations in the HNF4A gene is considerably less common (Table  1) than HNF1A mutations.

Since the possibility of mutations can be considerably greater in the latter setting, this can give rise to qualitative differences in the mutation-selection dynamics.

Insertional mutagenesis screens in animal models are particularly suited to addressing this issue, as they can provide large collections of tumors with tagged mutations that are considerably less complex at the molecular level than human cancer.

They found that, for small-effect alleles, the fixation probability is considerably increased relative to that from new mutations.