Sentence examples for mutations is challenging from inspiring English sources

Evaluating the functional significance of such mutations is challenging due to the difficulties in purifying such a large protein.

However, the identification of causal mutations is challenging due to the sheer number of variants that are identified in individual exomes.

The application of the GINI method to LCLs to identify transcripts harbouring germline truncating mutations is challenging due to a number of factors related to cell type, microarray sensitivity and variations in NMD efficiency.

The application of the GINI method to identify germline mutations is challenging due to limitations including microarray sensitivity in detecting small fold changes, and because of individual variations in nonsense-mediated mRNA decay efficiency [ 24, 50, 56, 59, 60, 63].

While the direct correlation of clinical severity with catalytic activity or thermostability of CdLS HDAC8 mutations is challenging, it is clear that the clinical phenotype is very sensitive to mutations that even slightly compromise activity or thermostability.

Distinguishing the driver from passenger mutations is challenging and the common approaches are to identify those genes harboring more mutations than expected given the average background mutation frequency for the cancer type.

32, 39 Making more precise estimates of the risk of these cancers associated with PALB2 germline mutations is challenged by several factors including the rarity of PALB2 mutations overall and the rarity of the cancers under consideration and the setting in which the majority of these studies have been conducted (ie, in highly selected families).

Furthermore, finding the one causal mutation is challenging considering the large number of genetic variations per individual.

Despite recent insights into melanoma genetics, systematic surveys for driver mutations are challenged by an abundance of passenger mutations caused by carcinogenic UV light exposure.

Obtaining a better date for the origin of the A111T mutation is challenged by a number of issues.

Forty four plants obtained from the selfing of Sl-eIF4E1 G1485A heterozygous, consequently segregating for the mutation, were challenged with PVY-LYE90 and PepMoV and genotyped for the mutation.