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Based on these novel findings, we hypothesize that muscle disease related to DNM2 mutations is caused by the production of dominantly active defective DNM2 proteins that interfere with the tubulation process.
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Each of these mutations was caused by the activity of endogenous and/or exogenous mutational processes with different strengths.
The results of phenotypic analysis suggest that LSE2 and LSE3 mutations are caused by the disruption of genes involved in the path of sucrose transport from mesophyll cells to phloem sieve elements in rice leaves.
Numerous types of resistance achieved by chromosomal mutations are caused by target alterations [11].
All sis mutations were caused by single locus recessive mutations (data not shown).
Mutations are caused by numeric changes or structural alterations in the genome.
The majority of human PLP1 mutations are caused by duplications; almost all others are caused by missense mutations.
Eleven out of 14 nonsense mutations were caused by complex mutations, the other three by point mutations.
Thirty out of 46 missense mutations were caused by point mutations and the remaining 16 by complex mutations (p = 0.004, data not shown).
Most of the beta-thalassemia mutations are caused by point mutations, small deletions or insertions within the coding regions and the exon-intron junctions.
The cms mutations are caused by deletions or rearrangements of the mitochrondrial genome and cause phenotypes only in some backgrounds (Schnable and Wise 1998).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com