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Introducing multiple site-directed mutations is also an important tool in the field of synthetic biology.
Acquiring a series of mutations is also probably how a bird flu gave rise to the 1918 pandemic.
Although the specific tissues affected by loss of PINK1 function differ in flies and humans, the fact that each of the tissues affected by PINK1 mutations in the fruitfly has mitochondrial defects strongly suggests that the neurodegeneration in humans with PINK1 mutations is also caused by mitochondrial dysfunction.
Here, we tested the extent to which the lethality associated with aux mutations is also be suppressed by Chc+ overexpression.
Inactivation of TP53 by somatic mutations is also associated to the panel of disruptions which are common for this "tumor suppressor" [113].
This suggests that the induction of mutations is also associated with genomic instability development during immortality acquirement, although it is still unclear how the mutations are induced.
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The spontaneous mutations were also attempted by using insertion sequence (IS) elements.
The PTPRS expression vectors containing various site and deletion mutations were also customarily ordered from GeneCopoeia.
These ZnF mutations were also introduced into a construct for expression in mammalian cells.
Other gene mutations are also known to increase risk.
These mutations are also providing important new insights into nuclear cytoplasmic interactions.
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