Sentence examples for mutations involves a from inspiring English sources

Proximity measurements taken during these trajectories suggest that DIIIS2 countercharges may be an important substrate of voltage sensor translocation during recovery, and that the effect of hypokalaemic periodic paralysis mutations involves a decreased interaction of those S2 countercharges with R3 as the S4 segment traverses the gating pore towards the resting state.

Although the effects of mexiletine have been investigated previously in another (V872G) NaV1.7 mutation in vitro, where it was shown to induce use-dependent current blocking effects (Choi et al., 2009), to our knowledge, this is the first evidence that the mechanism of action of mexiletine on erythromelalgia channel mutations involves an effect on their gating properties.

The most appealing initial target has been BRAF itself, as most mutations involve a single residue in the kinase domain of the protein.

If the dynamics of return to equilibrium are driven by local mutations involving a stepwise mutation model, then V returns to equilibrium much more slowly than HE.

Compensatory mutations involve changing both members of a base pair (i.e. GC→AT) to preserve the secondary structure, whereas consistent mutations involve a change to only one member of the pair while preserving secondary structure (i.e. GC→GU).

All new mutations involved a single nucleotide.

These so-called 'nonsense' mutations involve a PTC.

(B ) The codon mutations involve a mix of one-, two-, and three-nucleotide mutations.

In particular, most of these mutations involved a cytosine base that was preceded by a thymine base.

We identified 4 novel ETNK1 mutations involving a total 10 patients (N244S=6, N244T=1, N244K=1 and G245A=2; Figure 1).

Over 80% of the BRAF mutations involve a missense mutation that results in the substitution of glutamic acid for valine at amino acid 600 (V600E).