Sentence examples for mutations involve the from inspiring English sources

These mutations involve the replacement of specific phenylalanine residues, which circumscribe the cavity, with tyrosine, tryptophan, leucine and isoleucine.

Mutations involve the SLC34A3 gene, which encodes for NaPi-IIc (Na-dependent Pi cotransporter found in the proximal renal tubule).

Other mutations involve the P-loop (e.g. E255 K) and presumed regulatory regions of the enzyme (e.g. M351T) remote from the imatinib-binding site.

The BRAF locus is localized on chromosome 7q, and most BRAF mutations involve the kinase activation loop at the p.V600 position.

For top strand lesions, mutations involve the G of GpA, the complement of the C of TpC (see Figure 4 main text).

For example, D178N causes FFI, D202N causes GSS and E211Q causes CJD, yet all of these mutations involve the substitution of a negatively charged amino acid with a polar uncharged amino acid (Capellari et al., 2011; Kovács et al., 2002).

In terms of the APC gene, SBN have a lower rate of mutations involving the APC gene compared to its involvement in CRC [ 63].

There are no known missense mutations involving the free C residue, according to the NCL mutational database (http://www.ucl.ac.uk/ncl/), indicating that this residue is not critical for TPPI catalysis.

Clear cell renal carcinoma, the most common histologic subtype, is predominantly associated with mutations involving the von Hippel-Lindau gene and elaboration of vascular and somatic growth factors.

After several studies on relations between the mutations involving the core-binding factor A1 (CBFA1) on chromosome 6p21 and CCD were published, many studies have been conducted to determine the correlation between CBFA1 mutations and phenotypic variabilities [2].

This can happen via two pathways: (1) somatic gain-of-function mutations involving the IL6ST gene, which encodes the oncogene gp130 in 60%% of cases, and (2) STactivationtion without mutations in gp130 in 40%% of cases [38].