Sentence examples for mutations introduced in from inspiring English sources

To evaluate mutations introduced in the CRISPR/Cas9 transgenic plants, a region of about 300 bp surrounding the target locus of gRNA was amplified by PCR.

Second, mutations introduced in the DNA of a cell are inherited by its descendants, allowing the re-construction of lineage relationships.

Mutations introduced in an antibody germline sequence as a result of somatic hypermutation could cause its derivatives to have an altered affinity for its target.

Mutations introduced in the second coordination sphere of the T1 site shifted the pH activity profile and drastically reduced the inhibitory effect of chloride.

We show that relatively few mutations introduced in the 46M2 and 46M3 variants resulted in improved binding and neutralization of SUDV and confirmed the importance of the LC FR3 region to the binding interface.

The mutations introduced in A/H5N1HA Q222L,G224S Pby E627K by reverse genetics remained present in the virus population after 10 consecutive passages at a frequency >99.5% (Fig. 4 and table S1).

But Cornell researchers found a single mutation introduced in one individual spread to the entire population close to one-third of the time, assuming that the CRISPR allele perfectly converted its corresponding allele, and the introduced allele carried a fitness cost where an individual produced 40percentt fewer offspring.

Plasmids were also produced with single and double cysteine-to-alanine mutations and/or a D25A mutation introduced in the protease-coding region of pGPfs-1C.

The additional mutation introduced in S2, Ile80Phe, is located on the other side compared to the two mutations of S1 and introduces additional bulk there.

(C denotes a mutation introduced in the primer in order to generate a BssSI restriction site (CACGAG) in the C allele, while the T allele remains uncut).

It was shown that an A458T point mutation, introduced in the D loop of the GR (GRdim), impairs homodimerization and ablates DNA binding [ 21].