Sentence examples for mutations into this from inspiring English sources

To address the function of the UCR and its YY1-motif in an in vivo model of MLV host interactions we introduced six consecutive triple basepair mutations into this region of the potent T-lymphomagenic SL3-3 MLV.

Moreover, binding of such cross-reactive antibodies can be diminished by inserting mutations into this epitope in the E protein or in virus-like particles (VLPs) [ 16- 20].

Since the regulatory segment binds to Ca2+/CaM, it is difficult to introduce mutations into this segment without disturbing the interaction with calmodulin.

Apparently, introduction of the selected mutations into this already-optimized sequence has no (V9I and F67S) or a detrimental effect (F86Y and G138D).

Furthermore, we introduced the L366K and ΔHD1 single and double mutations into this C-terminal truncation, and also into the ΔC truncation of B9L [ 24], to ask whether the DN effect(s) would be abolished if β-catenin and/or Pygo binding was eliminated.

Six-helix bundle of CA-SP1 plays an important role in HIV-1 assembly and budding based on the observation that the introduction of structure-disrupting mutations into this region of Gag results in a defect in virus particle production 1, 17.

Introduction of a 3-bp substitution mutation into this ATF4-binding site essentially eliminated the PTH response.

After introduction of a point mutation into this seed sequence the construct is no longer repressed by injection of miR-10 (figure 2C).

Incorporation of the T63S mutation into this background (Kcv(TS), Figure 8A) reduced sensitivity to barium further and causes a change that when compared with the wild-type is in line with that seen in the Kir2.1 background (∼12 fold relative to wild type).

Introducing the E54D mutation into this construct (MNV/SVD1/E54D) had no effect on NS boundary cleavage.

For reasons not understood, it proved impossible to move the nanE mutation into this background on its own.