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Taken together, we hypothesized that each OPTN transgenic line would show distinct phenotype because of different locations of mutations, influencing different OPTN-interacting proteins.
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The specific KRAS mutation may thereby influence different aspects of tumor progression, which could explain why repeated KRAS targeting is observed in a subset of colorectal cancer.
Based on the previously presented evidence of independent domestications for indica and japonica we would expect that different suites of genes and corresponding mutations influencing domestication traits would have been selected within the different subspecies or subpopulations.
If so, how do different combinations of resistance mutations influence pathogen success?
This result was surprising since IIS and ife-2 mutations ostensibly influence very different aspects of the worm's physiology.
In exercise-trained pigs, the PRKAG3 mutation influences muscle characteristics and promotes an oxidative phenotype to a varying degree among muscles with different functions.
The fact that the total substrate turnovers depend on this entire set of protein properties is probably the reason why so many different mutations influence activity.
Optimal treatment of neuroblastoma (e.g. with tyrosine kinase inhibitors) requires a clearer understanding of how different ALK mutations influence protein function and, in turn, contribute to neuroblastoma development.
There, we described how the evaluation is influenced when different mutations of proteins from the training set are used for testing.
In sum, our results indicate that the different pathogenic mutations highly influence the dimerization behavior of human TPI under recombinant in vivo conditions.
Various studies have found a higher than expected mutation frequency of candidate cancer genes, and that the tumor properties could be influenced by different combinations of mutations [ 5- 8].
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