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Our understanding of the mechanisms by which mutations induce the disease still remains limited.
Here we asked two questions: when expressed on a different background (FVB), will activating Met mutations induce the same tumor type specificity?
Hotspot KRAS mutations induce the irreversible and continuous activation of RAS-dependent downstream signals.
IDH mutations induce the production of high quantities of 2-hydroxyglutarate [ 15].
This indicates the mutations induce the same destabilization of the eIF4A Pdcd4 interaction in Drosophila cells.
This suggests that Noonan and LEOPARD Shp2 mutations induce the same phenotype by activating or inhibiting pathway signalling.
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One of the principal factors of mutation inducing the upheavals and changes in the economic models of chemical industry is the improvement of the intrinsic sustainability of chemistry.
The R218 residue is a critical amino acid for Fluc activity and this mutation induces the synthesis of a protein with a strongly reduced luciferase activity [14].
This indicated that the 125G mutation induced the smaller, 20 kDa protein.
In human NSCs, the transfection of the tau minigene expressing the K298E mutation induced the overexpression of 4R tau (Fig. 2a).
Our in vitro data suggest that the K298E mutation induces the overproduction of mutant 4R tau, which is impaired in its ability to interact with microtubules.
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