Sentence examples for mutations induce an from inspiring English sources

Our results show that these mutations induce an exclusion of cations from the constriction zone of the channel, substantially reducing the flow of cations.

In HER-2/neu experimental tumors, the anti-apoptotic mutations induce an aberrant evolution of the stroma [8].

47 Activating KIT mutations induce an alteration of normal maturation and intracellular trafficking of receptor, and are associated with an intracellular activation of its immature form.

All mutations induce an overproduction of Aβ except the mutation V715M, in which, however, the ratio Aβ42/Aβ40 is increased [ 6].

This distribution, with 50% of mutations affecting one of the first two positions, at which nearly all mutations induce an amino-acid change, and 50% affecting the third position, at which half of all mutations induce an amino-acid change, is consistent with many mutations (75%) randomly affecting the DNA sequence being retained and not counter-selected.

The lack of correlation between expression on IHC and outcome is fully consistent with the previous report by Heinrich et al. Interestingly, Tabone-Eglinger et al (2008) have shown that GIST-type KIT mutations induce an activation-dependent alteration of normal maturation and trafficking, resulting in the intracellular retention of the activated kinase within the cell.

Specific mutations induce a preference for lysine relative to arginine.

Both FH and SDH mutations induce a state of pseudohypoxia, where 2-HG, fumarate or succinate can inhibit PHDs, resulting in stabilization of HIF.

These mutations induce a decrease of the enzymatic activity.

In humans, CRX mutations induce a variety of phenotypes of retinal degeneration [27].

Mutations induce a variety of molecular defects in ClC-1 channel function.