Thus, Notch1 mutations, being indispensable for the majority of clinical T-ALL, require additional mutations in order to drive the leukemogenic process.
In the context of evolutionary optimization, evolutionary operators, including crossover and mutation, are indispensable for solving a problem.
These findings broaden the spectrum of ALS-causing mutations and are indispensable for designing optimal strategies of mutational analysis and genetic counseling of ALS for patients of Chinese origin.
CS is caused by mutations in two genes indispensable for TC-NER, CSA and CSB.
If this hypothesis is true, the N51-to-A mutation should eliminate some interactions indispensable for deamination of C and retain/create interactions that ensure the deamination of 5 mC.
Lhp1 is not an essential protein, but it becomes indispensable for viability in strains harboring specific additional mutations.
This is indispensable for IKK activation upon TNF stimulation, as mutation of lysine 377 abolishes the ability of RIP to rescue IKK activation in RIP-deficient cells [ 38].
Mutations in RP genes reduce the efficiency of ribosome biogenesis, which is indispensable for immature erythrocytes in early and rapid growth phases [ 4].
Mutations in these lrx genes induce growth phenotypes implying that LRX proteins are indispensable for proper plant development.
Mutation of the NaV1.4 calmodulin-binding IQ motif showed that this domain is indispensable for normal channel expression and functioning (Biswas et al., 2008).
Considering that prolyl hydroxylation is indispensable for HIF-2α binding to pVHL, we next examined the notion that the A530V mutation negatively influences hydroxylation of HIF-2α via PHD2, which would attenuate HIF-2α A530V binding affinity for pVHL.
