Sentence examples for mutations indicating that from inspiring English sources
We conclude that there is no obligate role for furin cleavage in the activation of Notch1 by T-ALL-related NRR mutations, indicating that, as with ligand-mediated Notch activation, these mutations can activate signaling by causing conformational changes in the NRR, regardless of whether or not subunit dissociation can take place.
For most parameter values in case 1, α50% remains within the range of α for commonly observed mutator mutations, indicating that mutator pathways will have a significant role in tumorigenesis.
In addition, almost 80%% of highly expressed non-TE genes have insertion mutations, indicating that highly expressed genes in rice chromosomes are more likely to have mutations by mutagens such as T-DNA, Ds, dSpm and Tos17.
Although linear regression modeling is a statistical data-driven technique focused on obtaining the best possible prediction, many of these mutations are also known resistance-associated mutations, indicating that the statistical models largely reflect well characterized biological phenomena.
None of the non-synonymous SNPs result in nonsense mutations, indicating that no pseudogenes were created via this method.
Finally, 121 genes were differentially regulated not only in absence of PDR1 but also in the presence of GOF mutations, indicating that these genes might represent the basal set of PDR1-dependent genes.
Distinct gene mutations indicated that lizards from southern and southeastern Florida largely hailed from western Cuba.
At three locations where the chimp and human genomes were almost identical, telltale mutations indicated that it was impossible to get a viable protein from the chimp DNA sequence.
Overall, the analysis of the available EMS-induced mutations indicated that irrespective of their nature the phenotypic mutations all result in the loss of SUB function.
A detailed analysis of these mutations indicates that most of them are artifacts of the segmentation procedure, which creates very small segments in the normal samples that are not present in the tumor samples.
The presence of sequence variations and polymorphisms in CpG islands of L1 promoters that arise from transition mutations indicates that CpG methylation could play a significant role in determining the activity of L1 elements in the mouse genome.
