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The geographical distribution of some of the mutations indicated to be under selection was not random, and some mutations were private to artic populations.
Similar(59)
Non-synonymous amino acid mutations were indicated to have similar function (yellow) or altered polarity (blue), charge (pink) and aromatic nature (green).
PI3K mutation was indicated to be associated with ER positivity, HER2 negativity and primary tumor size, which were not observed in our study [ 37, 39, 40].
Repeated adaptation of a single p53 wild-type cell-derived clone of the neuroblastoma cell line UKF-NB-3 to nutlin-3 resulted in the establishment of sub-lines harbouring various p53 mutations, indicating nutlin-3 to induce de novo p53 mutations.
Eight out of ten nutlin-3-adapted sublines harboured six different p53 mutations, indicating nutlin-3 to induce the emergence of novel p53 mutations that were not present in the original cell population.
At three locations where the chimp and human genomes were almost identical, telltale mutations indicated that it was impossible to get a viable protein from the chimp DNA sequence.
Point mutations indicated in red showed reduced binding affinity to Usp.
Previous reports of the P333L mutation indicated insensitivity to SU therapy.
The frequently observed inactivating mutations indicated the important roles of chromatin remodeling complex in HCC development.
Distinct gene mutations indicated that lizards from southern and southeastern Florida largely hailed from western Cuba.
AP2 mutations indicated above.
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CEO of Professional Science Editing for Scientists @ prosciediting.com