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The sperm of older men contains a greater number of mutations, increasing the genetic disorders.
But because so many marry relatives — some 65percentt of Bedouin in Israel's Negev marry first or second cousins — they have a significantly higher chance of marrying someone who carries the same mutations, increasing the odds they will have children with genetic diseases, researchers say.
Recently, a role in both classical and atypical scrapie was assigned to new mutations, increasing the overall number of polymorphisms of interest for breeding plans.
However, the accumulation of experimental examples contradicting the hypothesis of antagonistic pleiotropy has highlighted the importance of other factors such as the epistasis between mutations increasing the adaptation to a new host.
When all the mutations are mapped onto the structure of the apoflavodoxin thermal-unfolding intermediate (obtained independently by equilibrium ϕ-analysis and NMR) they cluster perfectly so that the mutations increasing the relevant stability appear in the small unstructured region of the intermediate and the others in the native-like region.
HD is caused by mutations increasing the number of CAG repeats in exon 1 of the huntingtin gene (IT15), which is expressed in most cells of the human body [2].
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In all groups, the mutations increase the risk of certain other cancers as well.
It is anticipated that these mutations increased the local interactions that finally improved the thermostability and optimum temperature of luciferase.
Specifically, we envisage that KRAS mutations increase the intensity and duration of the growth-promoting signaling network.
Each mutation or a combination of these mutations increased the virulence of H9N2 virus in chickens and mice (Sun et al., 2013b).
In fact, the presence of the four HA mutations increased the reactivity with H5 antisera by twofold or more.
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