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The prevalence of D310 mutations increased significantly with the number of cytosines in the matched normal tissue sequence (P=0.02).
The prevalence of tumour D310 mutations increased significantly with the number of cytosines in the matched normal tissue sequence.
Moreover, in the present study, the prevalence of tumour D310 mutations increased significantly with the number of cytosines in the D310 sequence of matched normal tissues.
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Interestingly, the p.R76Q mutation increased significantly dimerization (127.8±6.6%), whereas the p.R76W mutation dramatically decreased it (30.5±9.0%).
APP carrying the E682K mutation increased significantly the Aβ1 42/Aβ1 40 ratio in cell-based assays.
Combined expression of pCas9 and pTpds in 1 1 ratio provided mutations that increased significantly when Cas9 and cgRNA were coexpressed using the construct pCtpds1 (Table 1).
Interestingly, mutation frequencies increased significantly (P<0.05) on exposure to H2O2 in the presence of higher CO2 levels (Fig 2).
The number of student models incorporating mutation, however, increased significantly on the final compared with the midterm (from 39 to 65%; chi-square test of independence, p < 0.0001).
The number of identified pseudogenes and mutations in the sequenced strain also increased significantly.
The proportion of infections with ≥ three mutations did not increase significantly on day 14 after non-ACT treatment (McNemar test p = 0.687) or after ACT treatment (McNemar test p = 0.250).
These mutations increased the transcriptional activity significantly, reaching 55% activity of wild-type TAp63γ, similar to the activity of dimeric p53 and TAp63γ mutants (Davison et al., 2001; Straub et al., 2010).
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