Sentence examples for mutations including both from inspiring English sources

Plasmids are genetically diverse and contain a range of mutations, including both beneficial mutations and neutral (or nearly neutral) mutations that may not confer a selective advantage, but are nonetheless commonly found.

Also, the same type of mutations, including both missense and in-frame deletion mutations of KARS, were observed with relative frequency of 0.74 in prostate cancers.

The capability of Xpd to synchronize thousands of nuclear divisions in a timely fashion was severely hampered in particular by four mutations, including both XP/CS alleles studied.

These mice developed a premature ageing phenotype including kyphosis, weight loss and osteoporosis, caused by an increase in somatic mtDNA mutations, including both point mutations and deletions (Trifunovic et al., 2004).

To identify nucleotide mutations, including both unknown mutations and those that have been reported in the dbSNP137 (http://www.ncbi.nlm.nih.gov/projects/SNP) and 1000 Genome Project (http://www.1000genomes.org), the genomic variations in the sequences were annotated with the ANNOVAR software [ 15].

The malignant transformation in AML has been proposed as the consequence of collaboration between several mutations, including both mutations in transcription factors resulting in impaired differentiation and constitutively activated receptor tyrosine kinases (RTKs), such as FLT3 and KIT, conferring proliferative and survival advantages to hematopoietic cells [ 3].

*Positivity for V Leiden and prothrombin mutations includes both heterozygotes and homozygotes; for the remaining assays it includes all results falling below the lower limit of the reported reference interval.

Alterations in mtDNA including both mutations and polymorphisms have the potential of changing the capacity of mitochondrial function.

Overall, five sequence alterations, including both mutations and polymorphism, were found in the abovementioned spots in the 12 samples from these patients.

The use of genome sequencing to discover mutations responsible for disease, including both inherited diseases and cancer, has exploded in recent years.

There have been few studies of short-term mitochondrial evolution, including both mutation rates and paternal leakage, particularly in non-human vertebrates [ 7, 8].