Sentence examples for mutations includes critical from inspiring English sources

The group of structural mutations includes critical mutations of the conserved cysteine residues (p.C42R, p.C42G, p.C46R, C179R and p.C200R), and four mutations of hydrophobic core residues to polar/charged residues (p.A110D, p.I122K, p.I122T, p.L154P).

The conclusion from the above studies is that the progression of MBL to CLL probably involves multiple pathophysiologic mechanisms including critical gene mutations and microenvironmental stimulation along with a CLL-prone genetic background [ 41].

In general, genes that are not expressed may accumulate mutations, including mutations in residues critical to the normal function of the protein.

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Examples of such "on" mutations are those substitutions that mimic activation loop phosphorylations, whereas examples of "off" mutations include those that alter catalytically essential residues of kinases, or residues in SH2 domains that are critical for phospho-tyrosine binding.

Other mutations include nonsense mutations, missense mutations and in-frame deletion (Everett, 2011).

Most mutations, including R882, occur within this tetramer interface.

The microarray-based resequencing system detected 35 kinds of mutations, including 23 new mutations.

In this work, we applied all mutation operators supported by Milu, that are divided in four categories: statement mutations, operator mutations, variable mutations, and constant mutations, including, for instance, the classical operators of arithmetic and logical operators replacement.

Majority of the mutations including nonsense and frame-shift mutations clearly disrupt LATS1/2 function; 2) Some mutations occurred in regions and residues important for LATS1/2 activation.