Sentence examples for mutations includes both from inspiring English sources

*Positivity for V Leiden and prothrombin mutations includes both heterozygotes and homozygotes; for the remaining assays it includes all results falling below the lower limit of the reported reference interval.

Plasmids are genetically diverse and contain a range of mutations, including both beneficial mutations and neutral (or nearly neutral) mutations that may not confer a selective advantage, but are nonetheless commonly found.

Also, the same type of mutations, including both missense and in-frame deletion mutations of KARS, were observed with relative frequency of 0.74 in prostate cancers.

The capability of Xpd to synchronize thousands of nuclear divisions in a timely fashion was severely hampered in particular by four mutations, including both XP/CS alleles studied.

These mice developed a premature ageing phenotype including kyphosis, weight loss and osteoporosis, caused by an increase in somatic mtDNA mutations, including both point mutations and deletions (Trifunovic et al., 2004).

The malignant transformation in AML has been proposed as the consequence of collaboration between several mutations, including both mutations in transcription factors resulting in impaired differentiation and constitutively activated receptor tyrosine kinases (RTKs), such as FLT3 and KIT, conferring proliferative and survival advantages to hematopoietic cells [ 3].

To identify nucleotide mutations, including both unknown mutations and those that have been reported in the dbSNP137 (http://www.ncbi.nlm.nih.gov/projects/SNP) and 1000 Genome Project (http://www.1000genomes.org), the genomic variations in the sequences were annotated with the ANNOVAR software [ 15].

In contrast, we found that noncoding mtDNA sequences harbored 35.8% of the total observed nodal mutations (including both RNMs and SNMs) and 49% of the RNMs, that is, 5-fold (χ test, P < 0.001) and 7-fold (χ test, P < 0.001) more than expected at random, respectively.

A comprehensive understanding of the dysregulated pathways and cellular consequences of TSC1 or TSC2 mutations, including both the canonical TORC1-dependent and the non-canonical TORC1-independent functions of TSC1/TSC2 and Rheb, is an essential step towards the development of effective long-term therapeutic strategies for individuals with TSC and LAM.

It is intriguing that the disease spectrum caused by VCP mutations similarly includes both ALS and FTD and that TDP-43 pathology occurs prominently in VCP linked disease.

Mutation testing for LS includes both sequencing and MLPA.