Sentence examples for mutations in the context of the from inspiring English sources
A similarly mutated E6 protein containing analogous cysteine to serine mutations in the context of the full length protein was shown to properly fold and to display in vitro and in vivo p53 degradation properties that were comparable to those of wild-type E6.
Understanding the effect of individual mutations in the context of the remaining genomic variation represents a major challenge to our interpretation of disease.
The cybrid cell model allows studying the effect of mtDNA mutations in the context of the same nuclear background [34].
Conditional mutagenesis systems permitting external control over the timing of genetic alterations are attractive as they allow phenotypic analyses of mutations in the context of the mature, or even aged, prostate gland.
The effect of point mutations in the context of the insertion of additional residues can be analyzed accordingly.
To explore the fitness landscape more systematically, we have introduced the 64 combinations of mutations in the context of the consensus sequence, and evaluated their functional impact.
Specifically, we used the bioinformatic tool Phobius to predict the SP character of all possible combinations of 'mutations' in the context of the consensus sequence, and by calculating the ratio of the resulting predicted activity over the predicted activity for the consensus sequence.
The software, called MuPIT Ebola Edition, enables a researcher to visualize Ebola gene mutations in the context of three-dimensional protein structures.
In this review we discuss recent work describing GluR mutations in the context of PNDDs.
Compensatory mutations in the context of proteins and cis-regulatory sequences are also well known [ 16].
The presence of 40%% BRAF and KRAS mutations in the context of 71 90 % estimated tumor cellularity in case P4 and the presence of 31 % BRAF mutation and 30%% KRAS mutation in the context of 51 70 % estimated tumor cellularity in case P5 suggest that the kinase-impaired BRAF mutation and the activating KRAS mutation were present in the all the tumor cells.
