Sentence examples for mutations in subjects from inspiring English sources

The data revealed an excess of mechanistically anticipated mutations in subjects treated with the drug, suggesting that VDA is applicable to human treatment.

Presence of low-abundance NNRTI mutations in subjects who were not on NNRTI-containing regimens may indicate longer elapsed time from last NNRTI use compared to subjects with high-abundance NNRTI mutations.

Analysis of the HCV non-structural protein NS2-NS5B sequences from sequential time-points of subjects with acute and early HCV infection revealed a total of 170 amino acid changes, the majority of which were maintained into chronic infection (108/143 mutations in subjects with multiple time-points; Table S1).

Our screening strategy did not, however, identify mutations in Subjects 1330 and 4021.

For FLG mutations in subjects without a history of AD, no effect could be shown (OR 0.7).

Mutations in subjects with hair occur in the ligand-binding domain, leaving the DNA-binding domain intact.

We sequenced the exons and splice junctions of the AMPK γ3 gene (PRKAG3) in 761 obese and 759 lean individuals, identifying 87 sequence variants including a novel R225W mutation in subjects from two unrelated families.

Because plasma levels of N-acylethanolamine analogues related to AEA, including PEA, OEA and LEA, are significantly elevated in severely obese carriers of the mutant FAAH 385 A alleles, this supports the concept of a functional FAAH enzyme mutation in subjects with FAAH 385 C→A SNPs.

The identification of a GCK mutation in subjects whose clinical phenotype is suggestive of MODY usually distinguishes patients with a benign prognosis (GCK MODY) from those with a severe hyperglycemia (HNF1A MODY and other MODY forms) because the diagnosis cannot be always made on clinical grounds alone.

Furthermore, they suggest that patterns of atrophy have the potential to be useful to help differentiate these groups and help predict the presence of the C9ORF72 gene mutation in subjects with behavioural variant FTD, regardless of the presence of family history.

Although overall efficacy results were comparable, rates of response were higher and emergence of PI resistance mutations lower in subjects on ATV plus RTV than with ATV alone.